The data are from 25 hospitals submitting inpatient and 25 hospitals submitting ED Uniform Bill (UB)-04 administrative claims from January 1, 2020–May 27, 2023. Even though the data are not nationally representative, they can provide insight into the use of opioids and other overdose drugs. The NHCS data is submitted from various types of hospitals (e.g., general/acute, children’s, etc.) and can show results from a variety of indicators related to drug use, such as overall drug use, comorbidities, and drug and polydrug overdose. NHCS data can also be used to report on patient conditions within the hospital over time.